Anatomical and functional outcomes of transcanalicular diode laser assisted dacryocystorhinostomy as a primary procedure.

INTRODUCTION: The goal of this study was to assess the efficacy of transcanalicular diode laser assisted dacryocystorhinostomy (TDL-DCR) for the treatment of primary acquired nasolacrimal duct obstruction. MATERIAL AND METHODS: This was a single center retrospective study. We included all patients who underwent TDL-DCR between July 2015 and October 2017 for chronic epiphora or chronic dacryocystitis. All procedures were performed under local anesthesia with sedation. The anatomical and functional success rates were studied as a function of each operative indication. RESULTS: Thirty-seven patients were included (18 had chronic epiphora and 19 had chronic dacryocystitis). All but one patient had bicanalicular silicone stent intubation. Irrigation of the lacrimal system demonstrated postoperative patency in 78% of patients operated for chronic epiphora and 76% of those with chronic dacryocystitis. The functional success of the surgery (as defined by the Munk score) was higher if the operative indication was chronic dacryocystitis (62%) (whereas it was only 41% for the indication of chronic epiphora). CONCLUSION: TDL-DCR has a lower anatomical and functional success rate than those reported in the literature for external or endonasal dacryocystorhinostomy. However, it retains a place in the treatment of primary acquired nasolacrimal duct obstruction (in particular when it is complicated by chronic dacryocystitis), especially if there is an absolute or relative contraindication to the two other dacryocystorhinostomy techniques.

Tratamiento del hiperparatiroidismo primario mediante abordaje mínimamente invasivo / Treatment of the primary hiperparatiroidism by minimally invasive boarding

The unilateral boarding of the primary hiperparatiroidism constitutes a technical option increasingly secondhand and adapted for the characteristics of this surgery. This type of boarding has been possible for the appearance of the Tc sestamibi, of the subspecialization of the surgery and of the determination of the PTH intraoperatory. Later we expose an epidemiological, descriptive and retrospective study from january 2004 to December 2008. During this time there were controlled in the hospital Ramon and Cajal of Madrid a total of 195 patients for primary hiperparatiroidism. Of them, 140 were submitted to unilateral exploration by suspicion of the solitary adenoma. The correlation between the findings of Tc sestamibi and surgical was correct in all the cases (139) except one concerns to right or left side. It failed in 30 cases in which there was detected badly the top and low location. As for the results the adenoma was extirpated correctly in 135 of 140 patients. This way we can say that the combination of the gammagraphy, a surgeon with experience and the support of the PTH intraoperatory they meet a high rate of treatment in case of adenomas in the unilateral boarding on a rate of hipercalcemia appellant or persistently between 3 percent-5 percent, rate similar to the obtained one for expert surgeons on having fulfilled an exploratory cervicotomy (considered "gold standard") but with minor postoperatory morbidity, minor pain and minor surgical time.

El abordaje unilateral del hiperparatiroidismo primario constituye una opción técnica cada vez más usada y apropiada debido a las características de esta cirugía. Este tipo de abordaje ha sido posible por la aparición del Tc sestamibi, de la subespecialización de la cirugía y de la determinación de la PTH intraoperatoria. A continuación exponemos un estudio epidemiológico, descriptivo y retrospectivo desde enero de 2004 a diciembre de 2008. Durante este tiempo fueron intervenidos en el hospital Ramón y Cajal de Madrid un total de 195 enfermos por hiperparatiroidismo primario. De ellos, 140 fueron sometidos a exploración unilateral por sospecha de adenoma único. La correlación entre los hallazgos gammagráficos y quirúrgicos fue correcta en todos los casos (139) menos uno en cuanto a lo que a lateralidad se refiere. Falló en 30 casos en los que se detectó mal la localización superior e inferior. En cuanto a los resultados, se extirpó el adenoma correctamente en 135 de los 140 pacientes. Así podemos decir que la combinación de la gammagrafía, de un cirujano con experiencia y el apoyo de la PTH intraoperatoria proporciona una elevada tasa de curación en el caso de adenomas paratiroideos en el abordaje unilateral con una tasa de hipercalcemia recurrente o persistente entre el 3 por ciento-5 por ciento, tasa similar a la obtenida por cirujanos expertos al realizar una cervicotomía exploradora (considerada gold standard) pero con menor morbilidad postoperatoria, menor dolor y menor tiempo quirúrgico.

Pseudoquiste de páncreas con extensión a mediastino / Pancreatic pseudocyst extended to the mediastinum: case report

We report a 53 years old male consulting for chest pain and dyspnea. On physical examination, an epigastric mass was detected. A TC scan showed a collection located in the omental bursa, which protruded over the posterior gastric wall and ascended to the mediastinum. Due to the presence of pancreatic calcifications, a pancreatic pseudocyst was suspected. The mediastinal cyst was drained percutaneously, leaving pig tail drainage in the cavity. Afterwards a cyst excision and Roux en Y gastrostomy was performed. After the surgical procedure the cyst became infected, requiring antimicrobials. After two weeks he was discharged in good conditions.

Los pseudoquistes de páncreas representan el 75 por ciento de las lesiones quísticas del páncreas y generalmente se circunscriben en el abdomen. Se presenta el caso de un paciente con un pseudoquiste de páncreas con extensión transhiatal a mediastino. Estos casos deben sospecharse mediante una historia clínica detallada y preguntando por antecedentes de dolor abdominal previo porque la clínica con la que se suelen manifestar es muy poco específica. El tratamiento de los pseudoquistes con extensión a mediastino debería ser el drenaje definitivo, bien de forma quirúrgica o endoscópica.

[GEITDAH consensus on attention deficit hyperactivity disorder]. / Consenso del GEITDAH sobre el trastorno por deficit de atencion/hiperactividad.

In this article, the GEITDAH -the Spanish abbreviation of the Special Interest Group on Attention Deficit Hyper-activity Disorder (ADHD)- presents a consensus reached by experts in the management of ADHD from all over Spain. The consensus concerns fundamental aspects that should be the starting point for future local or regional consensus guides. Another aim of this consensus is also to reduce the amount of variability that occurs in the health care offered to patients with ADHD in our country, as well as to act as a stimulus in educational matters. That fact that it is not very long will make it more popular among greater numbers of people and this will allow these goals to be reached more effectively. The conclusions in the consensus guide have been constructed around an introduction dealing with basic aspects and recommendations for diagnosis, treatment (both pharmacological and psychotherapeutic), patient flow and organisational aspects.

Screening for bipolar disorder in a Spanish sample of outpatients with current major depressive episode.

OBJECTIVE: Bipolar spectrum disorders often go unrecognised and undiagnosed or misdiagnosed. One of the underlying reasons is the poor recognition of bipolar disorder among patients presenting depressive episodes. The specific aim of this study was to estimate the Mood Disorder Questionnaire (MDQ) rate of positive screens for bipolar disorder in a Spanish sample of outpatients with a current major depressive episode and compare it with their current psychiatric diagnosis. The study was designed to address this specific question. METHOD: 971 consecutively outpatients with a current DSM-IV TR diagnosis of a major depressive episode entered this cross-sectional study. Study measures included sociodemographic and clinical data, Clinical Global Impression of Severity of Illness Scale (CGI-S), Hamilton Depression Scale (HAMD) and MDQ. RESULTS: 905 patients fulfilled criteria to be included in the analysis. All of them presented with a current major depressive episode. 74.3% (n=671) of the patients had received a diagnosis of unipolar depression and 25.7% (n=232) of bipolar disorder by a psychiatrist. Using a MDQ of 7-or-more-item threshold, the global positive screen rate for bipolar disorder was 41.3% (n=373). From the 671 patients with previous unipolar depression diagnosis, 161 (24%) screened positive for bipolar disorder with MDQ, whereas in 232 patients diagnosed of bipolar disorder, 212 (91.4%) screened positive for bipolar disorder. CONCLUSIONS: The MDQ showed a positive screen rate for bipolar disorder in 24% of patients with a previous diagnosis of unipolar disorder and a current major depressive episode. Screening tools like MDQ could contribute to increase detection of bipolar disorder in patients with depression. Early diagnosis of bipolar disorder may have important clinical and therapeutic implications in order to improve the illness course and the long-term functional outcome.

A 6-month prospective, observational, naturalistic, uncontrolled study to evaluate the effectiveness and tolerability of oral ziprasidone in patients with schizophrenia.

This multicenter, uncontrolled, naturalistic study evaluated the effectiveness and tolerability of 6 months of treatment with ziprasidone in 1266 patients with a diagnosis of schizophrenia. The percentage of responders (at least 30% reduction in PANSS total score) in the primary analysis sample (n=1022) was 47.3% (95% CI 44.2-50.4) at the end of the study. Patients showed a significant and clinically relevant reduction in the PANSS total, positive, negative and general psychopathology subscales scores (effect size of 1.60, 1.83, 0.62 and 1.40 respectively). Overall, 453 (35.8%) patients withdrew from the study; 9.3% withdrew owing to adverse events. Ziprasidone doses greater than 120 mg/day were associated with a lower risk of discontinuation for any cause (OR 0.46, 95% CI 0.33-0.65) Ziprasidone was well tolerated. Most common side effects were: insomnia, somnolence and nervousness. The effectiveness and tolerability of ziprasidone in clinical practice are consistent to those previously shown in the more restricted and homogeneous populations of clinical trials.

Ziprasidona: de la farmacología a la práctica clínica. Un año de experiencia / Ziprasidone: from pharmacology to the clinical practice. One year of experience

Transcurridos más de 2 años desde la comercialización del antipsicótico atípico ziprasidona, los datos procedentes de estudios de investigación y de la práctica clínica han proporcionado abundante información útil para su manejo práctico en el tratamiento de la esquizofrenia. Sus características farmacodinámicas y los resultados de los estudios clínicos con dosis flexible parecen justificar la necesidad de administrar dosis en el rango superior de las inicialmente previstas, con un mínimo inicial de 120 mg/día y una rápida titulación hasta 160 mg/día. Dichas dosis permiten alcanzar concentraciones plasmáticas que permiten ocupar al menos el 60 % de los receptores D2 del que se derivará el efecto antipsicótico. Además, se confirma su actividad antidepresiva y su perfil no sedante, con un posible efecto favorable sobre la atención y otras funciones cognitivas del paciente, en relación con la elevada afinidad frente a receptores 5HT1A y D1 y la inhibición de la recaptación de serotonina y noradrenalina.Por último, la escasa afinidad de este fármaco frente a receptores alpha-adrenérgicos, histamínicos y muscarínicos favorece un buen perfil de tolerabilidad, con un efecto neutro sobre el peso y falta de efectos anticolinérgicos. Los resultados de diversos ensayos clínicos muestran que el uso de dosis en el rango superior se asocia a una mejoría clínica más rápida y pronunciada que dosis inferiores, sin añadir un mayor riesgo de efectos adversos

More than a year after the marketing of the atypical anti-psychotic ziprasidone, data from research studies and clinical practice have provided a fair amount of useful information for its practical use in the treatment of schizophrenia. Its pharmacodynamical characteristics and the results from clinical trials with a flexible dose seem to justify the need to administer doses in a range higher than what was initially foreseen, with an initial minimum of 120 mg per day and a fast titulation up to 160 mg per day. Such doses make it possible to achieve sufficient plasma concentrations to occupy at least 60 % of the D2 receptors from which the anti-psychotic effect derives. Moreover, its anti-depressive activity and its non-sedative profile have been confirmed, with a favorable effect on attention and other cognitive functions of the patient, according to its high affinity for 5HT1A and D1 receptors and the inhibition of serotonin and noradrenaline re-uptake.Finally, the low affinity of this drug for á-adrenergic, histaminergic and muscarinic receptors favors a good tolerability profile, with a neutral effect on weight, and a lack of anti-cholinergic effects. Results from different clinical trials show that the use of doses in the higher range is associated to a faster and more pronounced clinical improvement without adding a higher risk of adverse events

Ziprasidone: from pharmacology to the clinical practice. One year of experience.

More than a year after the marketing of the atypical anti-psychotic ziprasidone, data from research studies and clinical practice have provided a fair amount of useful information for its practical use in the treatment of schizophrenia. Its pharmacodynamical characteristics and the results from clinical trials with a flexible dose seem to justify the need to administer doses in a range higher than what was initially foreseen, with an initial minimum of 120 mg per day and a fast titulation up to 160 mg per day. Such doses make it possible to achieve sufficient plasma concentrations to occupy at least 60 % of the D2 receptors from which the anti-psychotic effect derives. Moreover, its anti-depressive activity and its non-sedative profile have been confirmed, with a favorable effect on attention and other cognitive functions of the patient, according to its high affinity for 5HT1A and D1 receptors and the inhibition of serotonin and noradrenaline re-uptake. Finally, the low affinity of this drug for alpha-adrenergic, histaminergic and muscarinic receptors favors a good tolerability profile, with a neutral effect on weight, and a lack of anti-cholinergic effects. Results from different clinical trials show that the use of doses in the higher range is associated to a faster and more pronounced clinical improvement without adding a higher risk of adverse events.

Intoxicación con estricnina en un paciente adicto a drogas / Strychnine poisoning in a drug addict

La estricnina se emplea como rodenticida y suele ser causa de intoxicación accidental. Debido a su sabor amargo y su efecto anestésico local, se utiliza para adulterar drogas ilícitas como la cocaína y la heroína. Se presenta el caso de un joven adicto a la cocaína que ingresa con rigidez de los músculos de la cara, trismo, extensión y lateralización hacia la izquierda de la cabeza, fasciculaciones de los músculos de la cara y un episodio mayor con hiperextensión del cuerpo en pleno estado de lucidez. Se plantearon como diagnósticos diferenciales: abuso de drogas, encefalitis, rabia, epilepsia y tétanos. Los estudios de rutina fueron normales, el electroencefalograma demostró una patente epileptógena focal y el examen de orina confirmó la presencia de cocaína y estricnina. El tratamiento de la intoxicación con estricnina debe dirigirse a evitar las convulsiones y apoyar la función respiratoria; se debe tratar con diazepam y eventualmente anestésicos y bloqueadores neuromusculares. La evolución puede ser fatal por parálisis bulbar, rabdomiólisis, mioglobinuria y acidosis láctica. En pacientes con antecedentes de consumo de cocaína, la presencia de un cuadro similar al tétanos debería hacer pensar en intoxicación con estricnina ya que el diagnóstico y tratamiento temprano mejoran la supervivencia (AU)

Sertraline for the prevention of relapse in detoxicated alcohol dependent patients with a comorbid depressive disorder: a randomized controlled trial.

AIMS: We performed a double-blind, placebo-controlled randomized trial of sertraline in recently detoxified alcohol-dependent patients with current depressive symptoms. The objectives of the study were to evaluate the efficacy of sertraline at achieving stable abstinence, at ameliorating depressive symptoms and at improving quality of life in these patients. METHODS: The study included 83 patients, who received either sertraline (50-150 mg/day) or placebo for 24 weeks. The primary outcome criteria were the rate of relapse into alcohol consumption and the rate of response on the Montgomery and Asberg Depression Rating Scale (MADRS). RESULTS: At the end of the treatment period, relapse rates were 23.1% in the placebo group and 31.8% in the sertraline group. Responder rates for depression were 38.5% for the placebo group and 44.2% for the sertraline group. There was no significant difference between treatment groups with either variable. However, when patients were stratified into severe (MADRS score >or=26) and moderate (MADRS score <26) depression at inclusion, a significant treatment benefit with sertraline was observed in the former group. Quality of life, determined by the SF-36, improved in both groups, with more benefit observed for the sertraline group on mental health items. Sertraline was well tolerated, and the incidence of adverse events was similar in the two treatment groups. CONCLUSIONS: The explanation for the overall good outcome in both treatment groups and for the inability to demonstrate a clear treatment effect may reside in the clinical features of the patients included.

Inhibitors of farnesylation of Ras from a microbial natural products screening program.

Mutant ras oncogenes are associated with various human tumors such as pancreas, colon, lung, thyroid, bladder and several types of leukemia. Prenylation of Ras proteins plays a major role in cell proliferation of both normal and cancerous cells. Normal and oncogenic Ras proteins are posttranslationally modified by a farnesyl group that promotes membrane binding. Inhibitors of farnesyl protein transferase (FPTase), the enzyme that catalyzes the prenylation of Ras proteins, inhibit growth of tumor cells. In an effort to identify structurally diverse and unique inhibitors of FPTase, a program devoted to screening of natural products was initiated. This effort led to the identification of 10 different families of compounds, all of which selectively inhibit FPTase with a variety of mechanisms that are reviewed in this manuscript. These compounds originated from the fermentations of a number of microorganisms, either actinomycetes or fungi, isolated from different substrates collected in tropical and temperate areas. A chemotaxonomic discussion on the distribution of each compound among single or different types of microorganisms, either phylogenetically related or unrelated species, is included.

Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography.

We describe a protocol to manufacture 82Sr/82Rb generators and 82RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82Sr. The generators produced sterile and non-pyrogenic 82RbCl for i.v. injection. No significant 82Sr/85Sr breakthroughs were observed after elution with 20 1 of saline. The automated system delivered human doses of 82RbCl accurately.

[Evaluation of two methods to avoid the nephropathy associated with radiologic contrast]. / Estudio de dos métodos para evitar la nefropatía asociada a contraste radiológico.

UNLABELLED: Our objective was to establish the efficacy of two methods to avoid contrast associated nephropathy (C.A.N). We studied in prospective and randomized form a sample of 75 patients of whom 25 were assigned to the CONTROL GROUP: without interventions; 25 to the Saline group: 0.45% saline solution I.V., 1.5 cc/kg/min, 6 hours before and after the angiographic study and 25 to the Dopa group: equal procedure plus the aggregate of dopamine 2 micrograms/kg/min, 30 minutes before the study until the termination. The evaluation effected at patient's entry was considered T0, T1, 24 hs after the T2, 48 hs after. In T0 was registered: age, sex, pathological antecedents, drugs and plasmatic creatinine, and in T2 creatinine. An increase of 25% of the plasmatic creatinine in T2 was considered as C.A.N. The latter was present in 13/25 (OR: 1) CONTROL GROUP patients, 7/25 (OR 0.36), Salina group patients and in 5/25 (OR 0.23) Dopa group patients (p = 0.01). No significant difference was registered in the urinary output nor in the plasmatic creatinine levels. It is concluded that hydration during six hours before and after the study with 0.45% saline solution and the same plan with the aggregate of dopamine are effective to prevent a C.A.N.

Geranoyl-CoA carboxylase: a novel biotin-containing enzyme in plants.

Geranoyl-CoA carboxylase (EC 6.4.1.4) is a biotin-containing enzyme previously described in two genera of bacteria. Here we report the presence of geranoyl-CoA carboxylase in kingdom Plantae. Geranoyl-CoA carboxylase was purified 180-fold from maize leaves. The enzyme has a biotin-containing subunit of 122 kDa. The pH optimum for activity is 8.3. The apparent Km values for the substrates geranoyl-CoA, bicarbonate, and ATP are 64 +/- 5 microM, 0. 58 +/- 0.04 mM, and 8.4 +/- 0.4 microM, respectively. Subcellular fractionations indicate that geranoyl-CoA carboxylase is located in plastids. Geranoyl-CoA carboxylase activity is ubiquitous in organs of monocots and dicots and varies with development. We postulate that geranoyl-CoA carboxylase plays an important role in isoprenoid catabolism in plants, in a pathway analogous to that shown in Psuedomonas sp. In plants, this catabolic pathway would require the interaction of at least three subcellular compartments (plastids, microbodies, and mitochondria) and two biotin-containing enzymes, geranoyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase.

Estudio de dos métodos para evitar la nefropatía asociada a contraste radiológico. / [Evaluation of two methods to avoid the nephropathy associated with radiologic contrast]

Our objective was to establish the efficacy of two methods to avoid contrast associated nephropathy (C.A.N). We studied in prospective and randomized form a sample of 75 patients of whom 25 were assigned to the Control group: without interventions; 25 to the Saline group: 0.45

saline solution I.V., 1.5 cc/kg/min, 6 hours before and after the angiographic study and 25 to the Dopa group: equal procedure plus the aggregate of dopamine 2 micrograms/kg/min, 30 minutes before the study until the termination. The evaluation effected at patients entry was considered T0, T1, 24 hs after the T2, 48 hs after. In T0 was registered: age, sex, pathological antecedents, drugs and plasmatic creatinine, and in T2 creatinine. An increase of 25

of the plasmatic creatinine in T2 was considered as C.A.N. The latter was present in 13/25 (OR: 1) Control group patients, 7/25 (OR 0.36), Salina group patients and in 5/25 (OR 0.23) Dopa group patients (p = 0.01). No significant difference was registered in the urinary output nor in the plasmatic creatinine levels. It is concluded that hydration during six hours before and after the study with 0.45

saline solution and the same plan with the aggregate of dopamine are effective to prevent a C.A.N.

Síndrome pulmonar por varicela zoster / Syndrome of respiratory distress by Zoster chickenpox

El síndrome de distrés respiratorio del adulto por Varicela Zoster es una entidad de presentación infrecuente, con alta morbimortalidad en pacientes inmunocomprometidos y embarazadas. Para establecer el diagnóstico se requiere de un cuadro clínico y radiológico compatible, asociado a un foco de contagio y serología positiva. Caso clínico: Mujer de 30 años que ingresa a la unidad de terapia intensiva por dificultad respiratoria y erupción cutánea pápulo-vesículo-costrosa de 72 horas de evolución. Refería amenorrea de 4 semanas, por lo que se solicitó una ecografía obstétrica que confirmó la presencia de un embarazo de igual término. Exámen físico: febril, taquipneica, taquicárdica y con rales crepitantes en la mitad inferior del tórax. Laboratorio: VES acelerada, aumento de GOT, GTP y LDH, EAB: PH 7,47, PO 54, PCO 32, EB + 2,3, CO H 24, sat. Hb. 91 por ciento (FIO2 0,50), A-a 0 262, PAFI 108. Se solicitaron hemocultivos, urocultivos y ELISA para VVZ. Se trató con acyclovir 10 mg/kg cada 8 horas durante 15 días y ceftriaxona 2 gr/día por 10 días, mejorando su estado clínico. Al quinto día pudo ser desvinculada del respirador. El resultado del ELISA para VVZ fue reactivo. En el momento de ésta comunicación se encuentra en buen estado de salud cursando un embarazo normal. Comentarios: El síndrome de distrés respiratorio por varicela es una complicación grave de la enfermedad, por lo que es necesario adoptar medidas terapeúticas rápidas y agresivas ante su sospecha. Los diagnósticos diferenciales deben plantearse con todas las causas de neumopatía aguda extrahospitalaria y de SDRA (AU)

Síndrome pulmonar por varicela zoster / Syndrome of respiratory distress by Zoster chickenpox

El síndrome de distrés respiratorio del adulto por Varicela Zoster es una entidad de presentación infrecuente, con alta morbimortalidad en pacientes inmunocomprometidos y embarazadas. Para establecer el diagnóstico se requiere de un cuadro clínico y radiológico compatible, asociado a un foco de contagio y serología positiva. Caso clínico: Mujer de 30 años que ingresa a la unidad de terapia intensiva por dificultad respiratoria y erupción cutánea pápulo-vesículo-costrosa de 72 horas de evolución. Refería amenorrea de 4 semanas, por lo que se solicitó una ecografía obstétrica que confirmó la presencia de un embarazo de igual término. Exámen físico: febril, taquipneica, taquicárdica y con rales crepitantes en la mitad inferior del tórax. Laboratorio: VES acelerada, aumento de GOT, GTP y LDH, EAB: PH 7,47, PO 54, PCO 32, EB + 2,3, CO H 24, sat. Hb. 91 por ciento (FIO2 0,50), A-a 0 262, PAFI 108. Se solicitaron hemocultivos, urocultivos y ELISA para VVZ. Se trató con acyclovir 10 mg/kg cada 8 horas durante 15 días y ceftriaxona 2 gr/día por 10 días, mejorando su estado clínico. Al quinto día pudo ser desvinculada del respirador. El resultado del ELISA para VVZ fue reactivo. En el momento de ésta comunicación se encuentra en buen estado de salud cursando un embarazo normal. Comentarios: El síndrome de distrés respiratorio por varicela es una complicación grave de la enfermedad, por lo que es necesario adoptar medidas terapeúticas rápidas y agresivas ante su sospecha. Los diagnósticos diferenciales deben plantearse con todas las causas de neumopatía aguda extrahospitalaria y de SDRA

Síndrome pulmonar por Hantavirus: a propósito de un caso / Pulmonary syndrome by Hantavirus: a case report

La infección por Hantavirus es una patología transmitida por los roedores al ser humano y constituye una rareza dentro de las enfermedades infecciosas. Para su diagnóstico se requiere de alta sospecha clínica y noción de foco positivo para el contagio. Se presenta el caso de una mujer de 27 años que ingresó al Servicio de Clínica Médica por fiebre, mareos y mioartralgias de 5 días de duración. Los análisis de laboratorio eran normales y la radiografía de tórax no tenía alteraciones significativas. A las 36 horas presentó hipotensión, taquicardia y disnea creciente. La gasometría demostró una marcada hipoxemia sugerente de disfunción alveolo-capilar y la radiografía de tórax evidenciaba infiltrados densos intersticio alveolares bilaterales. La paciente fue trasladada a UTI donde se colocó en ARM. Monitoreo hemodinámico: PCP 12 mm Hg, IC 5,6 L/m/m², RVS 658 din/seg/cm. Se realizaron medidas de soporte habituales, tratamiento con ceftriaxone, clarittomicina y T + S pero la paciente falleció 63 horas después de su ingreso. A posteriori se recibió el resultado serológico positivo para Hantavirus realizado en el Centro de Virología de Pergamino. En éste caso se destaca la ausencia de antecedentes nosológicos de importancia, de una fuente de contagio evidente y de índice cardíaco bajo resistencia vascular sistémica elevada señalada por otros autores. Conclusiones: la afección pulmonar por Hantavirus debe considerarse en todo caso de distrés respiratorio del adulto aún en ausencia de antecedentes epidemiológicos evidentes

Síndrome pulmonar por Hantavirus: a propósito de un caso / Pulmonary syndrome by Hantavirus: a case report

La infección por Hantavirus es una patología transmitida por los roedores al ser humano y constituye una rareza dentro de las enfermedades infecciosas. Para su diagnóstico se requiere de alta sospecha clínica y noción de foco positivo para el contagio. Se presenta el caso de una mujer de 27 años que ingresó al Servicio de Clínica Médica por fiebre, mareos y mioartralgias de 5 días de duración. Los análisis de laboratorio eran normales y la radiografía de tórax no tenía alteraciones significativas. A las 36 horas presentó hipotensión, taquicardia y disnea creciente. La gasometría demostró una marcada hipoxemia sugerente de disfunción alveolo-capilar y la radiografía de tórax evidenciaba infiltrados densos intersticio alveolares bilaterales. La paciente fue trasladada a UTI donde se colocó en ARM. Monitoreo hemodinámico: PCP 12 mm Hg, IC 5,6 L/m/m², RVS 658 din/seg/cm. Se realizaron medidas de soporte habituales, tratamiento con ceftriaxone, clarittomicina y T + S pero la paciente falleció 63 horas después de su ingreso. A posteriori se recibió el resultado serológico positivo para Hantavirus realizado en el Centro de Virología de Pergamino. En éste caso se destaca la ausencia de antecedentes nosológicos de importancia, de una fuente de contagio evidente y de índice cardíaco bajo resistencia vascular sistémica elevada señalada por otros autores. Conclusiones: la afección pulmonar por Hantavirus debe considerarse en todo caso de distrés respiratorio del adulto aún en ausencia de antecedentes epidemiológicos evidentes (AU)

Pretargeted tumour imaging with streptavidin immunoconjugates of monoclonal antibody CC49 and 111In-DTPA-biocytin.

Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6 or 9 days later by 40 ng (250 microCi) of 111In-DTPA-biocytin. Tumors were visualized at 24 h postinjection of 111In-DTPA-biocytin. Tumour uptake was 0.9-2.5% injected dose/g with tumour/nontarget ratios from 2:1 to 37:1 (except for kidney, which was 0.5-3:1). Tumour uptake in mice pretargeted with streptavidin or streptavidin-conjugated nonspecific normal mouse IgG was < 0.1% i.d./g.